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Abstract
Context: Oxidative balance score (OBS) is a composite measure of multiple pro- and antioxidant exposures.
Objective: To investigate associations of OBS with F2-isoprostanes (FIP), mitochondrial DNA copy number (mtDNA), and fluorescent oxidative products (FOP), and assess inter-relationships among the biomarkers.
Methods: In a cross-sectional study, associations of a thirteen-component OBS with biomarker levels were assessed using multivariable regression models.
Results: Association of OBS with FIP, but not with FOP, was in the hypothesized direction. The results for mtDNA were unstable and analysis-dependent. The three biomarkers were not inter-correlated.
Conclusions: Different biomarkers of oxidative stress may reflect different biological processes.
Acknowledgements
We would like to thank the study participants for allowing us to conduct this work. We appreciate the contribution of Loree Mincey for processing the biological specimens.