Evaluation of miR-216a and miR-217 as potential biomarkers of acute pancreatic injury in rats and mice

David GoodwinDivision of Applied Regulatory Science, Center for Drug Evaluation and Research, US FDA MDUSA

Barry RosenzweigDivision of Applied Regulatory Science, Center for Drug Evaluation and Research, US FDA MDUSA

Jun ZhangDivision of Applied Regulatory Science, Center for Drug Evaluation and Research, US FDA MDUSA

Lin XuDivision of Applied Regulatory Science, Center for Drug Evaluation and Research, US FDA MDUSA

Sharron StewartDivision of Applied Regulatory Science, Center for Drug Evaluation and Research, US FDA MDUSA

Karol ThompsonDivision of Applied Regulatory Science, Center for Drug Evaluation and Research, US FDA MDUSA

Rodney RouseDivision of Applied Regulatory Science, Center for Drug Evaluation and Research, US FDA MDUSACorrespondence[email protected]

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Abstract

Mild injury of the exocrine pancreas is often asymptomatic and can be under- or mis-diagnosed. The pancreas-enriched microRNAs miR-216a and miR-217 were evaluated as potential serum biomarkers of exocrine pancreas injury in rodent models of acute pancreatitis induced by caerulein, l-arginine, and pancreatic duct ligation. Both microRNAs showed time- and dose- relevant responses to pancreatic injury and wider dynamic ranges of response than serum amylase or lipase. Pancreas-selective microRNAs were found to be relatively sensitive serum biomarkers of pancreatic injury in rodents with potentially greater specificity than the current standard assays.

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Evaluation of miR-216a and miR-217 as potential biomarkers of acute pancreatic injury in rats and mice

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Evaluation of miR-216a and miR-217 as potential biomarkers of acute pancreatic injury in rats and mice

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