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Abstract
Context: Acute phase proteins (APPs) are proposed as potential markers of the health status in pigs.
Objective: Circulating APPs in pigs co-infected with swine influenza virus and Pasteurella multocida.
Methods: Serum APPs were measured in co-infected and control pigs with the use of commercial ELISA tests.
Results: All investigated APPs revealed significant changes in co-infected pigs during the study period. The concentration of C-reactive protein, haptoglobin and serum amyloid A (SAA) increased significantly at 2 dpi, before respiratory signs and fever were observed. Concentration of Pig-MAP increased significantly at 3 dpi. C-reactive protein and SAA reaction were rapid but short-lived. The concentration of Hp and Pig-MAP in serum also increased at very early stage of co-infection but remained elevated for a longer period of time.
Conclusions: Maximal concentration of serum amyloid A correlated with the disease severity in pigs.
Declaration of interest
The authors report no declarations of interest. This work was supported by Polish Ministry of Science and Higher Education under grant no. N308 235938.