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Abstract
Context: Interleukin-27 is a new member of the IL-12 family which plays an important role in human carcinogenesis.
Objective: To investigate whether polymorphisms in IL27 contribute to renal cell carcinoma (RCC) risk.
Materials and methods: These two polymorphisms were genotyped in 329 RCC patients and 386 healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results: Significantly increased RCC risk was associated the G allele of both rs153109 and rs17855750 (rs153109: p = 0.006, OR = 1.364, 95%CI = 1.095–1.700; rs17855750: p = 0.001, OR = 1.768, 95%CI = 1.245–2.511).
Conclusion: The present study provided evidence that rs153109 and rs17855750 were associated with increased risk for RCC, suggesting an important role IL-27 may play in nephrocarcinogenesis.
Declaration of interest
No competing financial interests exist.
This work was supported by the National Natural Science Foundation of China (No. 81172440, No. 81172494, No. 81272821 and No. 81202023); the Applied Basic Research Programs of Science and Technology Commission Foundation of Sichuan Province (No. 2012SZ0026); and the Science Foundation for The Excellent Youth Scholars of Sichuan University (No. 2011SCU04A16).