Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy

Mehmet Enes CoşkunDepartment of Pediatrics, University of Gaziantep, Gaziantep, Turkey, Correspondence[email protected]

Mehmet KervancıoğluDepartment of Pediatrics, Pediatric Cardiology Division, University of Gaziantep, Gaziantep, Turkey,

Serdar ÖztuzcuDepartment of Medical Genetics, and

Fatma Yılmaz CoşkunDepartment of Cardiology, University of Gaziantep, Gaziantep, Turkey, and

Sercan ErgünDepartment of Medical Genetics, and

Osman BaşpınarDepartment of Pediatrics, Pediatric Cardiology Division, University of Gaziantep, Gaziantep, Turkey,

Metin KılınçDepartment of Pediatrics, University of Gaziantep, Gaziantep, Turkey,

Levent TemelDepartment of Pediatrics, Division of Pediatric Intensive Care, İstanbul University, İstanbul, Turkey

Mehmet Yavuz CoşkunDepartment of Pediatrics, University of Gaziantep, Gaziantep, Turkey,

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Abstract

Context: Dilated cardiomyopathy (DCM) is the most common cardiomyopathy in children. MicroRNAs (miRNA) are small RNAs which have regulatory functions in many biological processes.

Objective: We aimed to determine miRNA expression levels in plasma of children with DCM.

Materials and methods: Plasma expression levels of 379 miRNAs were compared between 23 DCM and 26 healthy children.

Results: The expression levels of miR-618, miR-875-3p, miR-205, miR-194, miR-302a, miR-147, and miR-544 were found decreased. The expression levels of miR-518f and miR-454 were found increased in DCM patients.

Discussion: miRNA level differences may provide the chance of using these miRNAs as new biomarkers.

Keywords

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Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy

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Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy

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