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Abstract
Objective: We studied the impact of chlorinated agents exposure on exhaled breath condensate (EBC) biomarkers in cleaners.
Methods: Malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), nitrites (), nitrates (
), pH, hydrogen peroxide (H2O2) and ammonium (
) were tested in EBC of 40 cleaners and 40 non-exposed controls. Pentraxin-3 (PTX3) and soluble type II receptor of IL-1 (sIL-1RII) were analyzed also in plasma.
Results: Levels of MDA-EBC, 4-HNE-EBC and -EBC were higher, while pH-EBC values were lower, in cleaners. MDA-EBC was associated with 4-HNE-EBC,
-EBC and pH. 4-HNE-EBC correlated with PTX3.
Conclusion: Professional exposure to chlorinated agents increases EBC biomarkers of oxidative stress and inflammation.
Acknowledgements
The authors would like to acknowledge the COPMA company for the support provided during subjects recruitment and data collection and the study participants for their time and willingness to participate in this study. The authors are grateful to Dr. Folesani Giuseppina who helped measuring EBC biomarkers.
Declaration of interest
This study was supported by research funding from the University of Ferrara. The authors report no conflict of interest.
Supplementary material available online