Is urine intercellular adhesion molecule-1 a marker of renal disorder in children with ureteropelvic junction obstruction?

Abstract

Aim: We aimed to investigate whether urine intercellular adhesion molecule-1 (ICAM-1) might serve as a marker of renal disorder in children with ureteropelvic junction obstruction.

Material and methods: Twenty-nine children with severe hydronephrosis (HN) were compared with 23 participants with mild HN and with 19 healthy peers.

Results: Urine ICAM-1/uCre levels were significantly higher in HN children than healthy controls (P <0.01), and in severe HN when compared with mild HN (p <0.05).

Conclusions: It seemed to us that uICAM-1 is a biomarker of renal disorder, and might have the potential to predict which patients will require surgery.

• Hydronephrosis
• marker
• renal disorder