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Abstract
This study aimed to evaluate changes in plasma amino acid and nicotinamide metabolites concentrations in rheumatoid arthritis (RA) in a search for potential biomarkers of the disease activity and the effect treatment. Analysis of plasma metabolite patterns with liquid chromatography/mass spectrometry revealed specific changes in RA as well as correlations with clinical parameters. Combined concentration parameter calculated as [aspartic acid] + [threonine] + [tryptophan] − [histidine] − [phenylalanine] offered the strongest correlation (p < 0.001) with pain joint count, swollen joint count and DAS 28. Such analysis of amino acid and related metabolite pattern offers potential for diagnosis as well as for monitoring disease progression and therapy in RA.
Declaration of interest
The authors declare no relation that could be perceived as conflict of interest. This study was supported by the European Union from the resources of the European Regional Development Fund under the Innovative Economy Program (a grant coordinated by JCET-UJ, No POIG.01.01.02-00-069/09) and TEAM program of the Foundation for Polish Science (TEAM/2011-8/7).