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Abstract
Time-course metabolic changes of aristolochic acid nephrotoxicity (AAN) was investigated using acute AAN HK-2 model. And the AAN-related biomarkers were selected. In the results, 11 potential identified biomarkers were selected and validated using multivariate method combined with time-course analysis. Several metabolic pathways, including vitamin metabolism, lipids acalytion, trytophan metabolism and protein degradation were found to be associated with AAN pathology. This research will provide a valuable reference for the discovery of more potential biomarkers of AAN progression in clinic.
Author contributions
Xiaoyan liu is responsible for main experiment working and article writing. Yanqiu Liu and Mengchun Cheng are responsible for technical support. Hongbin Xiao is responsible for the experiment design.
Declaration of interest
The authors declare no conflict of interests.
This work was supported by grants from National Technology Major Project (2014ZX09304307-001-006).
Supplementary material available online Supplementary Figures S1(a, b), S3 and S4