Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study

Premkumari KumarathasanAnalytical Biochemistry and Proteomics Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada, Correspondence[email protected]

Renaud VincentInhalation Toxicology Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada,

Agnieszka BieleckiAnalytical Biochemistry and Proteomics Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada,

Erica BlaisAnalytical Biochemistry and Proteomics Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada,

Katrin BlankAnalytical Biochemistry and Proteomics Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada,

Dharani DasAnalytical Biochemistry and Proteomics Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada,

Subramanian KarthikeyanInhalation Toxicology Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada,

Sabit CakmakPopulation Studies Division, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada, and

Mandy FisherPopulation Studies Division, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada, and

Tye ArbucklePopulation Studies Division, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada, and

William FraserDepartment of Obstetrics and Gynecology, University of Sherbrooke, Sherbrooke, QC, Canada

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Abstract

Background: There is paucity of information on mechanisms constituting adverse birth outcomes. We assessed here the relationship between vascular integrity and adverse birth effects.

Methods and results: Third trimester maternal plasma (n = 144) from the Maternal-Infant Research on Environmental Chemicals Study (MIREC) was analysed for vascular, inflammatory and oxidative stress markers by HPLC-fluorescence, protein array and EIA method. Analysis of the <25th and >75th percentile birth weight subgroups revealed markers associated with birth weight (ETs, MMP-9, VEGF, and 8-isoPGF-2α) and gestational age (ET-1, MMP-2, and VEGF).

Conclusions: Mechanistic insights into adverse birth outcome pathways can be achieved by integrating information on multiple biomarkers, physiology using systems biology approach.

Keywords

Acknowledgements

The authors would like to thank Dr. Anu Saravanamuthu for her technical assistance, as well as Dr. Gurusankar Saravanabhavan and Dr. Ella Atlas for internal review of the manuscript. The authors also acknowledge the valuable contribution of the MIREC participants and the MIREC Study group, especially the site investigators: Peter von Dadelszen, Denise Hemmings, Jingwei Wang, Michael Helewa, Shayne Taback, Mathew Sermer, Warren Foster, Greg Ross, Paul Fredette, Graeme Smith, Mark Walker, Roberta Shear and Linda Dodds.

Declaration of interest

The authors report that they have no conflicts of interest. This work was supported by the Chemicals Management Plan and the Clean Air Regulatory Agenda at Health Canada. The MIREC Research Platform is supported by the Chemicals Management Plan of Health Canada, the Canadian Institutes for Health Research (Grant # MOP – 81285), and the Ontario Ministry of the Environment. This study was supported by Health Canada federal government research funding.

Supplementary material available online

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Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study

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Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study

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