The roles of selenium, insulin-like growth factor binding protein 2 and suppressor of cytokine signaling 3 in the pathogenesis of Kashin–Beck disease

Sen WangSchool of Public Health, Health Science Center of Xi’an Jiaotong University, Xi’an, PR China and ;Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, PR China

Chen DuanSchool of Public Health, Health Science Center of Xi’an Jiaotong University, Xi’an, PR China and ;Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, PR China

Huan LiuSchool of Public Health, Health Science Center of Xi’an Jiaotong University, Xi’an, PR China and ;Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, PR China

Wanzhen ShaoSchool of Public Health, Health Science Center of Xi’an Jiaotong University, Xi’an, PR China and ;Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, PR China

Cuiyan WuSchool of Public Health, Health Science Center of Xi’an Jiaotong University, Xi’an, PR China and ;Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, PR China

Jing HanSchool of Public Health, Health Science Center of Xi’an Jiaotong University, Xi’an, PR China and

Xiong GuoSchool of Public Health, Health Science Center of Xi’an Jiaotong University, Xi’an, PR China and ;Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, PR ChinaCorrespondence[email protected]

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Abstract

We aimed to verify the levels of IGFBP2 and SOCS3 in cartilage and chondrocytes of Kashin–Beck disease (KBD) patients and the effects of different selenium concentrations on the protein expression levels. Chondrocytes were cultured with sodium selenite in vitro. Immunohistochemistry and western blotting were used to verify the protein expressions. IGFBP2 and SOCS3 were up-regulated in KBD chondrocytes and decreased with increasing selenium concentrations. IGFBP2 expressed highest in the middle zone of KBD cartilage, SOCS3 expressed higher in the middle and deep zone. IGFBP2 and SOCS3 may be the biomarkers for KBD diagnosis and evaluating the effect of selenium supplement.

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Declaration of interest

Authors have no conflict of interest. This study was supported by the National Natural Science Foundation of China (81402638, 81472924 and 81402639) and the Fundamental Research Funds for the Central Universities.

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The roles of selenium, insulin-like growth factor binding protein 2 and suppressor of cytokine signaling 3 in the pathogenesis of Kashin–Beck disease

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The roles of selenium, insulin-like growth factor binding protein 2 and suppressor of cytokine signaling 3 in the pathogenesis of Kashin–Beck disease

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