Monocyte subsets and monocyte-platelet aggregates: implications in predicting septic mortality among surgical critical illness patients

Abstract

Background: Monocyte subsets and monocyte–platelet aggregates (MPAs) play important roles in inflammation. Aim: To evaluate the association between the three human monocyte subsets and their contributions to MPAs and mortality among septic patients. Methods: Consecutive septic patients were enrolled in. Age- and gender-matched nonseptic patients were recruited as control patients. Monocyte subsets and monocyte–platelet aggregates were determined by flow cytometric analysis. Results: Elevated percentage of MPAs (MPAs%) was associated with an increased risk of mortality. Conclusions: This study demonstrated increased MPAs% enables the identification of a group of septic patients at high risk of death.

Keywords:

• Monocyte subset
• monocyte–platelet aggregates
• mortality
• sepsis

Acknowledgements

We want to express our thanks to Dr. Fan Zhang for his help in flow cytometric analysis.

Disclosure statement

The authors report no declarations of interest.

Funding information

The work was supported by grants from the National Natural Science Foundation of China (81270478).