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Research Article

Evaluation of mediators of oxidative stress and inflammation in patients with acute appendicitis

, , , , , , , , & show all
Pages 530-537 | Received 21 Mar 2015, Accepted 13 Feb 2016, Published online: 14 Apr 2016
 

Abstract

Context: This study aims to explore the potential of new inflammatory markers for improving the challenging diagnosis of acute appendicitis (AA).

Methods: Levels of IL-1, IL-6, IL-8, IL-10, CRP, INF-γ, and TNF-α in serum were measured in 73 patients with AA. Oxidative stress and antioxidant enzymes were analyzed.

Results: Serum levels of interleukins, TNF-α, and INF-γ were significantly elevated in patients with appendicitis (p < 0.0001), except for IL-10, which presented decreased levels. There were no significant differences in SOD (p = 0.29), CAT (p = 0.19), or TBARS levels (p = 0.18), whereas protein carbonyls presented significant increase (p < 0.0001).

Conclusion: Evaluating these biomarkers could aid in diagnosing AA.

Disclosure statement

The authors report no declarations of interest.

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