Risk factors for mortality in end-stage kidney disease patients under online-hemodiafiltration: three-year follow-up study

Abstract

The aim of this work was to evaluate the predictors of mortality in a group of end-stage kidney disease (ESRD) patients under dialysis, by performing a three-year follow-up study. From the 236 patients included in this study, 54 patients died during the three-year follow-up period. Our data showed that the risk of death was higher in patients presenting lower levels of mean cell hemoglobin concentration, transferrin, and albumin. Our study showed that poor nutritional status and an inflammatory-induced iron depleted erythropoiesis are important factors for mortality in these patients.

Keywords:

• End-stage kidney disease
• health-related quality of life
• inflammation
• iron metabolism
• mortality
• nutritional status
• online-hemodiafiltration

Disclosure statement

The authors declare no conflict of interest.

Veronica A. Poveda, MD, received support from the National Secretary of Higher Education, Science, Technology and Innovation “SENESCYT” and from the University Peninsula of Santa Elena, Santa Elena, Ecuador. This work is supported by FCT/MEC through national funds and co-financed by FEDER, under the Partnership Agreement (PT2020UID/MULTI/04378/2013 – POCI/01/0145/FERDER/007728); and by FCT (UID/Multi/04378/2013), COMPETE-FEDER.

Authors’ contribution

P.S.M., A.M., M.S.F., V.M., L.T., V.P., L.L., A.S.S., and E.C. participated in the design of the study. P.S.M., A.M., J.M., P.A., J.G.O., M.L., M.F., L.A., and M.S.F. carried data collection. P.S.M., A.M., L.T., E.M., and E.C. analyzed the results. P.S.M. wrote the first version of manuscript. E.C. conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.