Short-term effects of air pollution, markers of endothelial activation, and coagulation to predict major adverse cardiovascular events in patients with acute coronary syndrome: insights from AIRACOS study

Abstract

The aim of this study was to determine whether markers of inflammation and coagulation are associated with short-term particulate matter exposure and predict major adverse cardiovascular events at 360 d in patients with acute coronary syndrome (ACS). We included 307 consecutive patients, and assessed the average concentrations of data on atmospheric pollution in ambient air and meteorological variables from 1 d up to 7 d prior to admission. In patients with ACS, the markers of endothelial activation and coagulation, but not black carbon exposure, are associated with major adverse cardiovascular events at one-year follow-up.

Keywords:

• Acute coronary syndrome
• air pollution
• coagulation
• inflammation
• prognosis

Acknowledgements

Authors thank the following: Ms. Veronica Dominguez-Gonzalez for technical assistance and to Celine of JC OnLine Business Consulting for her linguistic revision of this manuscript.

Disclosure statement

The authors declare that they have no conflict of interest.

Funding information

This work was supported by Fondo de Investigación Sanatoria, Instituto de Salud Carlos III and Fondos FEDER (PI12/00092).