Systemic redox imbalance in stable chronic obstructive pulmonary disease

Abstract

Context: Increased oxidative burden is found in chronic obstructive pulmonary disease (COPD).

Objective: To assess the association of ceruloplasmin, albumin, bilirubin, transferrin, thiols and malondialdehyde (MDA) with stable COPD.

Materials and methods: Oxidative stress markers measured in 106 COPD patients and 45 healthy subjects were evaluated.

Results: Higher ceruloplasmin and MDA, and lower albumin, transferrin and thiols in COPD patients were found. Ceruloplasmin was the strongest single predictor of COPD. The model combining ceruloplasmin, albumin and thiols improved their individual diagnostic performances.

Conclusions: Diagnostic characteristics of ceruloplasmin, albumin, transferrin, thiols and MDA suggest their potential value as additional tools in disease diagnosis.

Keywords:

• Growth factors/cytokines/inflammatory mediators
• oxidative stress
• respiratory disease

Acknowledgements

Thanks to our colleague Dolores Pancirov for her contribution in participant's recruitment.

Disclosure statement

The authors declare no competing interests.

Funding information

This work was supported financially by the Croatian Ministry of Science, Education and Sports (grant number 006-0061245-0977).