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Abstract
Introduction: Oxidative stress induces atherosclerosis by triggering an inflammatory cascade within the vascular wall.
Objective: To investigate the role of pro-oxidant and antioxidant gene variations with CAD in Indian subjects.
Materials & methods: It’s a case-control study and genotyping for the variants MPO G-463A, CYBA G640A, SOD2 Val16Ala and CAT C-262T were performed by conventional PCR techniques.
Results: Only CYBA G640A variant allele was found to be significantly (p = 0.0075) associated with CAD.
Conclusion: Although CYBA G640A variation was found to be significant, a larger study is needed to validate these results and establish its role as a biomarker.
Acknowledgements
The authors are grateful to all the study subjects for their participation in the study.
Disclosure statement
There is no actual or potential conflict of interest capable of influencing the judgment on the part of any authors.
Funding information
This study was funded by National Health and Education Society (NHES) of P. D. Hinduja National Hospital and Medical Research Center. The funding body however had no role in the study design, collection, analysis and interpretation of data or in the decision to submit the article for publication.