Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors

Nod Charlton Sacktor Department of Neurology, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, Maryland, MD, 21224, USA

Richard L Skolasky Department of Epidemiology, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, Maryland, MD, 21224, USA

Robert H Lyles Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road, NE Atlanta, Georgia, GA, 30322, USA

Doreen Esposito Department of Neurology, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, Maryland, MD, 21224, USA

Ola A Seines Department of Neurology, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, Maryland, MD, 21224, USA

Justin C McArthur Department of Neurology, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, Maryland, MD, 21224, USA

Abstract

A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P=0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < −1.0) at baseline, 18 (78%) improved on the GP non-dominant hand test after initiating HAART (P=0.001). GP non-dominant hand performance improved longitudinally in HIV+ patients initiating HAART, while matched HIV+ controls not on HAART did not change (P=0.045). Significant improvement in motor performance can occur after HAART in HIV+ patients with impairment.

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Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors

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Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors

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