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Original Article

Increased quinolinate immunoreactivity in the peripheral blood monocytes/macrophages from SIVinfected monkeys

, , , , , , & show all
Pages 433-438 | Received 08 Apr 1996, Accepted 19 Jun 1996, Published online: 10 Jul 2009
 

Abstract

Quinolinate (QUIN), a metabolite in the kynurenine pathway of tryptophan degradation and a neurotoxin that is thought to act through the NMD A receptor system, was localized in cultured peripheral blood monocytes/macrophages from SIV-infected monkeys using a recently developed imrnunohistochemical method. Significant increases in QUIN immunoreactive (IR) cells were detected in all five SIV-infected monkeys examined. Multinucleated giant cells, a hallmark of lentiviral infection, were visible in selected samples. Treatment with the QUIN precursors, tryptophan and kynurenine, increased the number of QUIN-IR cells in both the control and SIV-infected preparations, perhaps by a mass action mechanism. We hypothesize that in SIV-infected monkeys, infiltrating monocytes/macrophages contribute to the high level of brain QUIN and associated neuropathology.

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