Abstract
Consideration is given to the relative merits of two methods of desensitization: the intradermal relief-dose (provocation-neutralization serial dilution titration) method, and the method of subcutaneous ‘maximum tolerated dose’; the former utilizes intrader-mally determined optimal strength allergen doses that require no incremental increase and provide rapid relief with no side effects; and the latter uses incrementally stronger doses, with signijcant attendant risks. There is discussion of the several advantages of the relief-dose method over the maximum tolerated dose method, among them that the former may include both offending foods and inhalants whereas the latter includes only inhalants.