Clozapine-induced myoclonic seizures and valproic acid

Abstract

Within a 3-year period, in 220 patients receiving clozapine, we observed myoclonic seizures in two who had no previous epileptic history. Seizures appeared at the titration phase at relatively low doses, and resolved with the addition of valproic acid, allowing further increases of the clozapine dose to therapeutic levels.

Key Words:

• myoclonic seizures
• schizophrenia
• clozapine
• valproic acid