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Medical Mycology Volume 50, 2012 - Issue 7
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Research Article

Experimental murine model of disseminated infection by Saksenaea vasiformis: successful treatment with posaconazole

Valentina Salas *Unitat de Microbiologia
,
F. Javier Pastor *Unitat de Microbiologia
,
Enrique Calvo *Unitat de Microbiologia
,
Deanna SuttonFungus Testing Laboratory University of Texas Health Science Center, San Antonio, Texas, USA
,
Dea García-HermosoInstitut Pasteur, Molecular Mycology Unit, and National Reference Center of Mycoses and Antifungal Agents;CNRS URA3012, Paris, Cedex 15, France
,
Emilio Mayayo *Unitat de Microbiologia;Unitat de Anatomia Patològica Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain
,
Françoise DromerInstitut Pasteur, Molecular Mycology Unit, and National Reference Center of Mycoses and Antifungal Agents;CNRS URA3012, Paris, Cedex 15, France
,
Anette FothergillFungus Testing Laboratory University of Texas Health Science Center, San Antonio, Texas, USA
,
Eduardo Alvarez *Unitat de Microbiologia
&
Josep Guarro *Unitat de MicrobiologiaCorrespondence[email protected]
 show all
Pages 710-715 | Received 15 Dec 2011, Accepted 03 Mar 2012, Published online: 29 Mar 2012
 

Abstract

We have determined the in vitro activity of amphotericin B (AMB) and posaconazole (PSC) against Saksenaea vasiformis using broth microdilution and disk diffusion methods and determined the minimal fungicidal concentration (MFC). PSC was found to have the greatest in vitro activity in all cases and was the most efficacious in prolonging survival and reducing the fungal load in an immunocompetent murine model of disseminated infection caused by four strains of the fungus.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and the writing of the paper.

This paper was first published online on Early online on 2 April 2012.

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Related Research Data

Notes for genera: basal clades of Fungi (including Aphelidiomycota, Basidiobolomycota, Blastocladiomycota, Calcarisporiellomycota, Caulochytriomycota, Chytridiomycota, Entomophthoromycota, Glomeromycota, Kickxellomycota, Monoblepharomycota, Mortierellomycota, Mucoromycota, Neocallimastigomycota, Olpidiomycota, Rozellomycota and Zoopagomycota)
Source: Springer Science and Business Media LLC

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