Investigation of antidiabetic action of Antidesma bunius extract in type 1 diabetes

Abstract

Context: Antidesma bunius L (Phyllanthaceae) is commonly known to local people in North-east Thailand as a medicinal plant. Objectives: To investigate hypoglycaemic activities of methanolic extract of A. bunius in type 1 diabetes. Materials and methods: A daily dose of A. bunius extract (250 mg/kg body weight) was given orally to alloxan-induced diabetic rats for 28 days. Blood glucose, insulin, TC, TG, amylase, lipase, liver glycogen were analysed. Results: Extract revealed a significant reduction in blood glucose level (80.5%) along with an increase in serum insulin (134%), lipase (90.7%) and liver glycogen level (160%). Also amylase (28.2%) activity, TC (40.2%), and TG (28.8%) levels were significantly decreased when compared with diabetic control rats. A. bunius extract improved the histo-architectural of the β-cells. Discussion and conclusion: The results suggested that A. bunius extract possess anti-diabetic activity, through the enhancement of hepatic glycogen storage and regeneration of the islet of Langerhans.

• Alloxan
• insulin
• liver glycogen
• TC
• TG

Acknowledgements

The authors are grateful to Professor Adel B. Kolosy, Pathology Department, Faculty of Medicine, Cairo University, Egypt, for his assistance in the histopathological study.

Declaration of interest

The authors declare that there is no conflict of interest.