Age, weight and decompression sickness in rats

Peter BuzzacottLaboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, Université de Bretagne Occidentale, Brest Cedex, France, ;The School of Sports Science, Exercise and Health, The University of Western Australia, Crawley, WA, Australia, and Correspondence[email protected]

Michael TheronLaboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, Université de Bretagne Occidentale, Brest Cedex, France,

Aleksandra MazurLaboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, Université de Bretagne Occidentale, Brest Cedex, France,

Qiong WangLaboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, Université de Bretagne Occidentale, Brest Cedex, France,

Kate LambrechtsLaboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, Université de Bretagne Occidentale, Brest Cedex, France,

Ingrid EftedalDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway

Simin Berenji ArdestaniDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway

François GuerreroLaboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, Université de Bretagne Occidentale, Brest Cedex, France,

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Abstract

Objective: The aim of this study was to determine if, after controlling for weight, age is associated with decompression sickness (DCS) in rats. Methods: Following compression-decompression, male rats aged 11 weeks were observed for DCS. After two weeks recovery, surviving rats were re-dived using the same compression-decompression profile. Results: In this experiment, there was a clear difference between DCS outcome at ages 11 or 13 weeks in matched rats (p = 0.002). Discussion: Even with weight included in the model, age was significantly associated with DCS (p = 0.01), yet after removal of weight the association was much stronger (p = 0.002). Conclusion: We believe that age is likely to be found associated with the probability of DCS in a larger dataset with a wider range of parameters, after accounting for the effect of weight.

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Age, weight and decompression sickness in rats

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Age, weight and decompression sickness in rats

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