Role of arginase in sciatectomized muscle

Abstract

Substrate kinetics of arginase were investigated in normal and sciatectomized gastrocnemius muscle of frog.

Sciatectomized muscle arginase showed 47 % elevation in V while K_m showed no change.

Sciatectomic activation of muscle arginase accounted for the stepped up urea levels which may be of significant use in combating ammonia toxicity and maintaining chemohomeostasis.