Ototoxicité à Long Terme De La Gentamicine Chez Le Rat : Recherche D'Une Atteinte Rétro-cochléaire Par L'étude Des Potentials évoquès Auditifs Du Tronc Cérébral

Abstract

Four groups of rats treated with single (50 mg/kg and 200 mg/kg) or multiple (3 × 200 mg/kg and 5 × 200 mg/kg) doses of gentamycin were studied over a 6-month period and compared with a control group.

At 50 mg/kg no significant changes were observed. Significant signs of intoxication were observed at 200 mg/kg doses and at multiple doses.

A significant lengthening of the latencies with changes in amplitude and a transitional increase in the auditory threshold were observed as early as the end of treatment. This was followed by a phase of amplitude decrease, a rise in auditory threshold and a decrease in latencies which remains unexplained.