Using Brine Shrimp to Determine Structure-activity Relationships Among Lupin Alkaloids

N. R. Ferrigni Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana, 47907, USA

B. N. Meyer Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana, 47907, USA

J. L. McLaughlin Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana, 47907, USA

W. J. Keller School of Pharmacy, Northeast Louisiana University, Monroe, Louisiana, 71209, USA

Abstract

The simple and convenient brine shrimp, Anemia salina (Leach), bioassay has been used to evaluate the activities of 13 known lupin alkaloids. Data from this study have revealed interesting structure-activity relationships. α-Isosparteine was by far the most active of these lupin alkaloids, suggesting that further pharmacologic testing of this compound may be warranted.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Using Brine Shrimp to Determine Structure-activity Relationships Among Lupin Alkaloids

Information for

Open access

Opportunities

Help and information

Using Brine Shrimp to Determine Structure-activity Relationships Among Lupin Alkaloids

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature