Hypocholesterolaemic Effect of a Crude Drug Mixture of Pakistani Herbs in Rabbits

Abstract

A mixture of indigenous herbs (Prunus bokharensis. Berberis arisiata. Nymphaea lotus and Rosa indica) was studied for its hypcholesterolaemic effect in rabbits. The drug mixture was given orally in the form of a decoction in doses of 0.5g. Ig or 2g per kg body weight per day to cholesterol-fed and normal rabbits. The drug mixture caused significant decreases in serum cholesterol levels of hypercholesterolaemic rabbits in doses of 1 or 2g/kg/d, after one week. At the doses tested, the drug mixture did not decrease the serum cholesterol level of normal rabbits after two weeks of drug administration.