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Abstract
The analgesic activity of fixed oil from the seeds of Ocimum sanctum (Tulsi) was studied after intraperitoneal injection in mice and rats using the tail flick, tail clip, tail immersion and acetic acid-induced writhing methods; results were compared with morphine and aspirin. It was found that O. sanctum failed to raise the pain threshold which indicated that analgesic activity is not centrally mediated. Using the acetic acid-induced writhing method, the oil showed significant inhibition in a dose-dependent manner suggesting its possible mechanism related to the peripheral system.
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