Bioassay-Guided Isolation and Identification of Linoleic Acid: A Guanosine Diphosphate/G-Protein RAS Exchange (GDPX) Inhibitor from Aspergillus

Sarath P. Gunasekera Harbor Branch Oceanographic Institution, Inc., 5600 U.S. 1, North, Fort Pierce, Florida, 34946, USA

Susan H. Sennett Harbor Branch Oceanographic Institution, Inc., 5600 U.S. 1, North, Fort Pierce, Florida, 34946, USA

Kathleen E. Janda Harbor Branch Oceanographic Institution, Inc., 5600 U.S. 1, North, Fort Pierce, Florida, 34946, USA

Robert W. Bryant Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey, 07033, USA

Abstract

An extract of an Aspergillus sp. (HBOI strain D245) was found to inhibit guanosine diphosphate/G-protein RAS exchange (GDPX). Bioassay-guided purification led to the isolation of linoleic acid (1). 1 gave significant inhibition in the GDPX assay, while methyl linoleate (2) was inactive. In this paper we report the isolation, identification and biological activity of 1.

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Bioassay-Guided Isolation and Identification of Linoleic Acid: A Guanosine Diphosphate/G-Protein RAS Exchange (GDPX) Inhibitor from Aspergillus

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Bioassay-Guided Isolation and Identification of Linoleic Acid: A Guanosine Diphosphate/G-Protein RAS Exchange (GDPX) Inhibitor from Aspergillus

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