Synthesis and Antimuscarinic Activity of Tropine Nonanoate

Yogendra N. Shukla Department of Medicinal Chemistry, College of Pharmacy and Pharmacal Sciences, Howard University, Washington, DC, 20059, USA

Richard K. Gordon Department of Applied Biochemistry, Division of Biochemistry, Walter Reed Army Institute of Research, Washington, DC, 20307-5100, USA

Govind J. Kapadia Department of Medicinal Chemistry, College of Pharmacy and Pharmacal Sciences, Howard University, Washington, DC, 20059, USA

Abstract

The recently isolated tropine nonanoate from Duboisia myoporoides R. Brown (Solanaceae) was synthesized, and the sulfate and hydrochloride salts were prepared. In addition, the ¹H- and ¹³C-NMR spectral data is reported. Finally, the antimuscarinic potency of the synthesized sulfate of tropine nonanoate was compared to atropine sulfate in a radioligand binding assay.

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Synthesis and Antimuscarinic Activity of Tropine Nonanoate

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Synthesis and Antimuscarinic Activity of Tropine Nonanoate

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