Myocardial Protective Effect of Maintained Beta-Blockade in Aorto-Coronary Bypass Surgery

H. Berggren Department of Thoracic and Cardiovascular Surgery, Internal Medicine, University of Gothenburg, Sweden

R. Ekroth Department of Thoracic and Cardiovascular Surgery, Internal Medicine, University of Gothenburg, Sweden

J. Herlitz Department of Thoracic and Cardiovascular Surgery, Internal Medicine, University of Gothenburg, Sweden

Å. Hjalmarson Department of Thoracic and Cardiovascular Surgery, Internal Medicine, University of Gothenburg, Sweden

D. Schlossman Department of Roentgenology, University of Gothenburg, Sweden

A. Waldenström Department of Thoracic and Cardiovascular Surgery, Internal Medicine, University of Gothenburg, Sweden

J. Waldenström Department of Clinical Chemistry, Sahlgrenska Sjukhuset, University of Gothenburg, Sweden

C. William Olsson Department of Thoracic and Cardiovascular Surgery, Internal Medicine, University of Gothenburg, Sweden

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Abstract

Twenty-nine patients were randomly allocated to two groups before undergoing aorto-coronary bypass surgery. In one group the beta-blocking medication was withdrawn three days preoperatively, and in the other group it was maintained. The patients in the latter group were additionally given 100 mg metoprolol per os two hours before surgery. The degree of myocardial injury, as judged from cumulated activity of S-CK B, was less when the beta-blockade was maintained.

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Myocardial Protective Effect of Maintained Beta-Blockade in Aorto-Coronary Bypass Surgery

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Myocardial Protective Effect of Maintained Beta-Blockade in Aorto-Coronary Bypass Surgery

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