Interleukin-1-related genes polymorphisms in Turkish patients with Behçet disease: a meta-analysis

Abstract

Objectives. Polymorphisms in the Interleukin (IL)-1-related genes at the locations –889, –511, + 3962 and mspa1l 1100 have been investigated for possible association with Behçet's disease (BD).

Methods. A literature-based search was conducted to identify all relevant studies. Five independent studies from Turkish population met the included criteria.

Results. IL-1α –889 CT [odds ratio (OR) = 0.72, 95% confidence interval (CI) = 0.55–0.95], IL-1α –889 TT (OR = 0.61, 95% CI = 0.40–0.93), IL-1β + 3962 C (OR = 1.41, 95% CI = 1.07–1.88), IL-1β + 3962 T (OR = 0.71, 95% CI = 0.53–0.94) IL-1β + 3962 CC (OR = 2.08, 95% CI = 1.08–3.99), IL-1β + 3962 CT (OR = 0.58, 95% CI = 0.38–0.88), IL-1 receptor antagonist (IL-1 Ra) mspa1l 1100 CT (OR = 0.69, 95% CI = 0.49–0.96), IL-1 Ra mspa1l 1100 TT (OR = 1.50, 95% CI = 1.08–2.08) had a significant association with BD. The pooled estimates for IL-1α –889 C, IL-1α –889 CC, IL-1α –889 T had a non-significant association with BD.

Conclusions. IL-1α –889 CT, IL-1α –889 TT, IL-1β + 3962 C, IL-1β + 3962 T, IL-1β + 3962 CC, IL-1β + 3962 CT, IL-1 Ra mspa1l 1100 CT, IL-1Ra mspa1l 1100 TT promoter polymorphisms may confer susceptibility to BD in Turkish population.

Keywords:

• Behçet's disease
• Interleukin-1
• Meta-analysis
• Polymorphisms

Conflict of interest

None.