A case of angioimmunoblastic T-cell lymphoma with high serum VEGF preceded by RS3PE syndrome

Tetsuya TabeyaDepartment of Gastroenterology, Rheumatology and Clinical Immunology Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan;Department of Internal Medicine, Dohkohkai Hospital, Sapporo, Hokkaido, JapanCorrespondence[email protected]

Toshiaki SugayaDepartment of Gastroenterology, Rheumatology and Clinical Immunology Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan

Chisako SuzukiDepartment of Gastroenterology, Rheumatology and Clinical Immunology Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan

Motohisa YamamotoDepartment of Gastroenterology, Rheumatology and Clinical Immunology Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan

Takayuki KanasekiDepartment of Pathology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan

Hiroko NoguchiDepartment of Pathology, Teine Keijinkai Hospital, Sapporo, Hokkaido, Japan

Yasuyoshi NaishiroDepartment of Gastroenterology, Rheumatology and Clinical Immunology Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan

Tadao IshidaDepartment of Gastroenterology, Rheumatology and Clinical Immunology Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan

Hiroki TakahashiDepartment of Gastroenterology, Rheumatology and Clinical Immunology Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan

Yasuhisa ShinomuraDepartment of Gastroenterology, Rheumatology and Clinical Immunology Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan

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Abstract

We report the case of a 76-year-old man diagnosed with angioimmunoblastic T-cell lymphoma (AITL) with high serum vascular endothelial growth factor (VEGF) preceded by Remitting seronegative symmetrical synovitis with pitting edema syndrome. He suffered respiratory discomfort caused by large amounts of pleural effusion. Interestingly, changes in serum VEGF measured over time were similar to changes in pleural effusion. Whether VEGF is related to the pathological condition of AITL is a very important question.

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A case of angioimmunoblastic T-cell lymphoma with high serum VEGF preceded by RS3PE syndrome

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A case of angioimmunoblastic T-cell lymphoma with high serum VEGF preceded by RS3PE syndrome

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