Diffuse large B-cell lymphoma of the lacrimal sac arising from a patient with IgG4-related disease

Hidenori MarunakaDepartment of Otolaryngology, National Hospital Organization Okayama Medical Center, Okayama, Japan,

Yorihisa OritaDepartment of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, Correspondence[email protected]

Tomoyasu TachibanaDepartment of Otolaryngology, Himeji Red Cross Hospital, Hyogo, Japan,

Kentaro MikiDepartment of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan,

Takuma MakinoDepartment of Otolaryngology, Himeji Red Cross Hospital, Hyogo, Japan,

Tadashi YoshinoDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, and

Kazunori NishizakiDepartment of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan,

Yasuharu SatoDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, and ;Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama, Japan

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Abstract

A rare case of diffuse large B-cell lymphoma (DLBCL) possibly induced by IgG4-related disease is described. A 78-year-old woman was presented with a mass of the right lacrimal sac that extended to the inferior nasal meatus through the nasolacrimal duct. Pathological diagnosis was DLBCL with diffuse distribution of IgG4 + cells in the background of this lesion. The chronic inflammatory state of IgG4-related disease could have caused the development of DLBCL.

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Diffuse large B-cell lymphoma of the lacrimal sac arising from a patient with IgG4-related disease

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Diffuse large B-cell lymphoma of the lacrimal sac arising from a patient with IgG4-related disease

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