Steroid-resistant protein-losing gastroenteropathy complicated with Sjögren’s syndrome successfully treated with mizoribine

Abstract

A 64-year-old woman with leg edema was diagnosed with protein-losing gastroenteropathy and Sjögren’s syndrome. Central venous nutrition led to infection of her catheter, ascites, and deep vein thrombosis. Following successful treatment of these conditions with antibiotics and anticoagulants, she was treated unsuccessfully with prednisolone and steroid pulse therapy. Mizoribine add-on markedly reduced edema and normalized serum albumin. This is the first report of a steroid-resistant protein-losing gastroenteropathy patient with Sjögren’s syndrome successfully treated with mizoribine.

Keywords:

• Mizoribine
• Sjögren’s syndrome
• Steroid-resistant PLGE

Conflict of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.