Abstract
Background aims. Recalcitrant diabetic wounds are not responsive to the most common treatments. Bone marrow-derived stem cell transplantation is used for the healing of chronic lower extremity wounds. Methods. We report on the treatment of eight patients with aggressive, refractory diabetic wounds. The marrow-derived cells were injected/applied topically into the wound along with platelets, fibrin glue and bone marrow-impregnated collagen matrix. Results. Four weeks after treatment, the wound was completely closed in three patients and significantly reduced in the remaining five patients. Conclusions. Our study suggests that the combination of the components mentioned can be used safely in order to synergize the effect of chronic wound healing.
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Acknowledgments
The authors thank Biohellenika SA Biotechnology Company and Khorasan Razavi Blood Transfusion Center for providing the consumables, and Medical Sciences of Mashhad University for providing the facilities that enabled completion of this study.
Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.