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Research Article

Synthesis and leishmanicidal activity of 2,3,4-substituted-5-imidazolones

, , , , &
Pages 29-37 | Received 15 Jan 2009, Accepted 25 Mar 2009, Published online: 23 Dec 2009
 

Abstract

Twenty-nine imidazolones 1–29 were synthesized and were randomly screened for their in vitro anti-leishmanial potential. Compound 17 showed a good anti-leishmanial activity with an IC50 value of 12.98 ± 0.32 μg/mL. Compounds 14 and 24 were also found to be moderately active (IC50 values 28.20 ± 0.03 and 41.12 ± 0.32 μg/mL, respectively). The activity was compared with that of standard drugs, amphotericin B (IC50 = 0.12 ± 0.41 μg/mL) and pentamidine (IC50 = 2.56 ± 0.10 μg/mL).

Acknowledgements

This work was financially supported by the Pakistan Telecommunication Company Limited (PTCL) through a research grant (“Synthesis of Leishmanicidal Chemotherapeutic Agents”).

Declaration of interest: The authors report no conflicts of interest.

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