Synthesis of some imidazolyl-thioacetyl-pyrazolinone derivatives and their antinociceptive and anticancer activities

Abstract

In this study, some 4-(1,5-diarylimidazol-2-yl)thioacetyl-1-phenyl-2,3-dimethyl-3-pyrazoline-5-one derivatives were prepared by reacting 4-(2-chloroacetyl)-1-phenyl-2,3-dimethyl-3-pyrazoline-5-one and 2-mercapto-1, 5-diarylimidazole derivatives. The antinociceptive and anticancer activities of the compounds obtained were investigated. It was observed that some of the compounds, 2a, 2d, 2g, and 2j, showed remarkable antinociceptive activity, and one of the compounds, 2i, showed weak anticancer activity.

Keywords::

• 1,5-diarylimidazole-2-thione
• 3-pyrazoline-5-one
• antinociceptive activity
• anticancer activity

Acknowledgements

The authors present their thanks to NCI (USA) and Anadolu University BIBAM (Turkey) AAQfor Anticancer test results and NMR spectral data respectively.

Declaration of interest: The authors report no conflicts of interest.