Abstract
In an effort to discover new candidates with improved antimicrobial activities we report here the synthesis and in vitro biological evalution of various series of 2-(N-methylamino)-4-(N,N-dimethylamino)-6-(arylthioureido)-s-triazine (5a–j) and (N-methylamino)-4-(N,N-dimethylamino)-6-(arylureido)-s-triazine (6a–j). All the synthesized compounds were screened in vitro for their antibacterial activity against two different gram-positive bacteria (S. aureus, B. subtilis) and two different gram-negative bacteria (P. aeruginosa, E. coli) using the broth dilution method.
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Acknowledgements
The authors are thankful to Dr. U. C. Pande, Head, Department of Chemistry and Director, School of Sciences, Gujarat University, for his kind cooperation, and Dr. Mrugesh Shukla, Microbiology Department, M. G. Sciences, for his guidance in obtaining MIC values. Characterization data were done at the Zydus Research Center.
Declaration of interest: The authors report no conflicts of interest.