Abstract
We report the synthesis and the in vitro insulin releasing and glucose uptake activity of the morpholino thiazolyl-2,4-thiazolidinediones (1-15). Compounds 5, 11–15 (at lower concentration; 0.001 mg/ml) were able to increase insulin release in the presence of 5.6 mmol/l glucose. The compounds, except derivative 3 show an increase of glucose uptake. Various compounds are interesting potential antidiabetic leads showing pancreatic and extrapancreatic effects.
Acknowledgement
This work was supported by Research Organization of Ankara University, Turkey (No: 09B3336003) and Hacettepe University Syntific Research Department (Project number: 04A602004). The skillful help undergraduate Ummu Duzgun.
Declaration of interest
The authors report no conflicts of interest.