Inhibition of Human Lymphocyte Cyclic Nucleotide Phosphodiesterases by the Chlorinated Adenosine Analog DTA-35

Abstract

Human (E†)-T-lymphocytes have multiple cyclic nucleotide phosphodiesterase activities, some of which are markedly inhibited by the chlorinated adenosine derivative 9-(3′,5′-dichloro-2′,3′,5′-trideoxy-β-D-rtreo-pentofuranosyl)adenine (DTA-35).

Key Words: :

• Phosphodiesterase
• cyclic nucleotides
• chlorinated adenosine analog