Measurement of Aromatisation by a Urine Technique Suitable for the Evaluation of Aromatase Inhibitors in Vivo

S. Jacobs Department of Academic Biochemistry, Royal Marsden Hospital, London and Surrey; Department of Medicine, Royal Marsden Hospital, London and Surrey

P. E. Lønning Department of Academic Biochemistry, Royal Marsden Hospital, London and Surrey

B. Haynes Section of Drug Development, Institute of Cancer Research, Surrey

L. Griggs Section of Drug Development, Institute of Cancer Research, Surrey

M. Dowsett Department of Academic Biochemistry, Royal Marsden Hospital, London and Surrey

Abstract

By modification of a recently developed method for separation of radio-labelled urinary oestrogens we were able to separate oestrogen metabolites and measure their isotope ratios in urine following injections of [³H]Δ⁴-androstenedione and [¹⁴C]oestrone. This method provides a useful tool for studying in vivo aromatisation of Δ⁴-androstenedione into oestrone in breast cancer patients before and during treatment with aromatase inhibitors.

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Measurement of Aromatisation by a Urine Technique Suitable for the Evaluation of Aromatase Inhibitors in Vivo

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