The Biological Activity of Atrial Natriuretic Factor Cleaved by Endoprotease 3.4.24.11

R. D. Ghai Research Department, Pharmaceuticals Division, CIBA-GEIGY Corporation, Summit, New Jersey, 07901

R. L. Webb Research Department, Pharmaceuticals Division, CIBA-GEIGY Corporation, Summit, New Jersey, 07901

J. L. Sonnenberg Research Department, Pharmaceuticals Division, CIBA-GEIGY Corporation, Summit, New Jersey, 07901

Y. Sakane Research Department, Pharmaceuticals Division, CIBA-GEIGY Corporation, Summit, New Jersey, 07901

G. Ghai Research Department, Pharmaceuticals Division, CIBA-GEIGY Corporation, Summit, New Jersey, 07901

Abstract

Ring cleavage of atrial natriuretic peptide (ANF) between Cys7 and PheH by endoprotease 3.4.24.11 yields X-ANF. Since endoprotease 3.4.24.11 may contribute to ANF metabolism in vivo. the present study determined if X-ANF exhibits reduced biological activity in comparison to the parent molecule.

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The Biological Activity of Atrial Natriuretic Factor Cleaved by Endoprotease 3.4.24.11

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