Correlations Between the In Vitro and In Vivo Activity of Anti-HIV Agents: Implications for Future Drug Deyelopment

Abstract

Some 10 years after the first recognition of acquired immunodeficiency syndrome (AIDS) as a new syndrome, we have identified a number of molecular targets to interrupt the replicative cycle of human immunodeficiency virus (HIV), the causative agent. A number of dideoxynucleosides have been identified as having anti-HIV activity in vitro, and several of these have been found to have clinical activity in patients. In contrast. while a number of agents have been found to block viral binding to the target cell in vitro, these agents have generally not shown clear-cut evidence of clinical activity. Agents which act at a variet) of steps in the HIV replicative cycle are now under development, and it is likely that we will have an increased armamentarium to fight this disease in the near future.

Key Words: :

• Anti-HIV agents
• CD4
• AZT
• zidovudine
• ddC
• ddl
• reverse transcriptase
• HIV-protease