A Tridimensional Representation of Enzyme Inhibition Useful for Diagnostic Purposes

Rui Fontes Servigo de Química Fisiológica, Faculdade de Medicina, Hospital de To, Universidade do Porto, Porto, Portugal

Joao Meireles Ribeiro Departamento de Bioquímica y Biología Molecular Genética, Facultad de Medicina, Universidad de Extremadura, E-06080, Badajoz, Spain

Antonio Sillero Departamento de Bioquímica, Instituto de Investigaciones Biomédicas del Consejo Superior de Investigaciones Científicas, Facultad de Medicina, Universidad Autónoma de Madrid, E-28029, Madrid, Spain

Abstract

A new three dimensional representation of enzyme inhibition, applied to Lineweaver-Burk, Hanes and Eadie-Hofstee plots is presented. This type of representation has advantages for enzyme inhibition diagnosis, showing graphic characteristics that pass unnoticed in linear plots.

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A Tridimensional Representation of Enzyme Inhibition Useful for Diagnostic Purposes

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