Sar Studies of Fluorine-Substituted Benzylamines and Substituted 2-Phenylethylamines as Substrates and Inactivators of Monoamine Oxidase B

Abstract

To test whether addition of electron-withdrawing substituents to good substrates of monoamine oxi-dase (MAO) will transform them into inactivators, a series of fluorine-substituted benzylamines and a series of substituted 2-phenylethylamines were synthesized and tested as substrates and inactivators of monoamine oxidase B. All of the compounds were substrates. None of the benzylamines was an inactivator, but several of the phenethylamines were. These results suggest that either stronger electron withdrawing character or additional stabilizing factors are needed to stabilize the hypothesized enzyme adduct.

Key Words: :

• Structure-activity relationships
• fluorinated benzylamines
• substituted 2-phenylethylamines
• monoamine oxidase B