Piperastatin A, A New Selective Serine Carboxypeptidase Inhibitor Produced by Actinomycete Ii. Physico-Chemical Properties and Structure Determination

Shoichi Murakami Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Sinagawa-ku, Tokyo, 141, Japan

Yoshikazu Takahashi Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Sinagawa-ku, Tokyo, 141, Japan

Hiroshi Naganawa Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Sinagawa-ku, Tokyo, 141, Japan

Tomio Takeuchi Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Sinagawa-ku, Tokyo, 141, Japan

Takaaki Aoyagi Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Sinagawa-ku, Tokyo, 141, Japan; Showa College of Pharmaceutical Sciences, 3-3165 Higashitamagawagakuen, Machida-shi, Tokyo, 194, Japan

Abstract

Piperastatin A, a new inhibitor of serine carboxypeptidase, was discovered in the culture broth of Streptomyces lavendofoliae MJ908-WF13. The molecular formula of piperastatin A was established as C₃₈H₆₇N₉C₁₀ by HRFAB-MS and elemental analysis. The structure was determined to be N-formyl-aWo Ile-Thr-Leu-Val-Pip-Leu-Pip (Pip = hexahydropyridadine-3-carboxylic acid) by various spectral analyses of piperastatin A and piperastatin A methylester.

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Piperastatin A, A New Selective Serine Carboxypeptidase Inhibitor Produced by Actinomycete Ii. Physico-Chemical Properties and Structure Determination

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Piperastatin A, A New Selective Serine Carboxypeptidase Inhibitor Produced by Actinomycete Ii. Physico-Chemical Properties and Structure Determination

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