Cytosolic and Mitochondrial Enzymes Inactivation by Uroporphyrin in Light and Darkness

Susana Graciela Afonso Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), University of Buenos Aires, Argentine

Rafael Enriquez De Salamanca Unidad de Porfirias, Hospital Universitario Doce de Octubre, Madrid, Spain

Alcira Maria Del Carmen Batlle Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), University of Buenos Aires, Argentine

Abstract

The effect of uroporphyrin I (UI) on several cytosolic and mitochondrial enzymes (succinyl CoA synthetase, ζ-aminolevulinic acid synthetase, rhodanese, lactate dehydrogenase) has been examined. All the enzymes were inactivated in the presence of the porphyrin both in the dark and under UV light.

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Cytosolic and Mitochondrial Enzymes Inactivation by Uroporphyrin in Light and Darkness

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Cytosolic and Mitochondrial Enzymes Inactivation by Uroporphyrin in Light and Darkness

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