Optimal laboratory panel for predicting preeclampsia

Abstract

Objective. This study was undertaken to investigate the usefulness of standard biochemical and hematological parameters measurement at third trimester of pregnancy for the individual prediction of preeclampsia.

Methods. A retrospective designed study included 113 patients with preeclampsia and a control group of 95 normal, uncomplicated pregnancies. Patients were recruited in the third trimester of pregnancy at the Department of Gynecology and Obstetrics, General Hospital Celje, Slovenia, EU. Erythrocytes, leukocytes, thrombocytes, hemoglobin, hematocrit, aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transferase, alkaline phosphatase, total bilirubin, urea, creatinine, uric acid, body mass index, parity, and age were evaluated to predict the occurrence of preeclampsia based on multivariate logistic regression model.

Results. When parameters such as uric acid and urea were included into logistic regression model, we correctly classified 79.6% patients. With additional four parameters (thrombocytes, hematocrit, aspartate aminotransferase and leukocytes) we correctly classified 83.8% patients with preeclampsia.

Conclusion. Our findings confirmed that several standard biochemical and hematological parameters, when used as laboratory test panel have significant prognostic value in the prediction of preeclampsia.

Keywords:

• Preeclampsia
• biochemical markers
• hematological markers
• 3rd trimester
• prediction
• laboratory panel
• uric acid
• urea
• thrombocytes
• hematocrit
• aspartate aminotransferase
• leukocytes

Acknowledgement

We would like to thank primarius Vladimir Weber, MD, (Head of the Department of Obstetrics and Gynecology, General Hospital, Celje, Slovenia) for giving opportunity this study to realize. We would also like to thank Štefka Krivec, MSc., (Head of the Department of the laboratory medicine of the same hospital), for providing additional information regarding the laboratory results.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.